Abstract
Background
The development of platelet concentrated biomaterials has gained increasing awareness for regenerative medicine. With different protocol, derivatives such as advanced platelet‐rich fibrin (A‐PRF), injected PRF (I‐PRF) and concentrated growth factors (CGF) have been demonstrated effectively in pre‐clinical and clinical studies. The aim of this study was to compare the level of growth factors releasing from A‐PRF and CGF, and their clinical efficacy in the regenerative management of intrabony defects (IBDs).
Methods
Thirty‐two blood samples were collected from 8 healthy donors and assessed for PDGF‐AB, VEGF, BMP‐2 and TGF‐β1 release at indicated times. In addition, the clinical records of forty‐five patients (15 per group) who had undergone guided tissue regeneration (GTR) with or without A‐PRF/CGF were retrieved. The probing pocket depth (PPD) and clinical attachment level (CAL) were recorded preoperatively and 6 months postoperatively. Intrabony component (IC) depth, radiographic bone level (RBL) and bone defect filling were assessed radiographically.
Results
A‐PRF had a looser fibrin network than the CGF but presented larger amounts of growth factors with a more sustained release period. Although there was no difference in PPD reduction, CAL gain, RBL height change and defect filling (%) between A‐PRF and CGF group, both achieved a more favorable clinical result in IC height reduction and defect filling (%) than the control.
Conclusion
A‐PRF and CGF have the ability to stimulate a continual and steady release of total growth factors over a 14‐day period. A‐PRF and CGF show a similar effectiveness in periodontal bone regeneration with a potential benefit of improving GTR outcomes in IBD treatment.
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https://aap.onlinelibrary.wiley.com/doi/abs/10.1002/JPER.19-0290?af=R
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