Abstract
Background
Dental implant failures still occur because of peri‐implant diseases such as peri‐implantitis. The objective of this study was to treat peri‐implantitis in beagle dogs by fabricating minocycline hydrochloride loaded graphene oxide films on implant abutment surfaces.
Methods
Beagle dogs with silk ligature were used to establish the peri‐implantitis model. Modified sulcus bleeding index, peri‐implant probing pocket depth, radiographic evaluation, Micro‐CT tomography analysis, and histological evaluation were determined to evaluate the therapeutic effect of minocycline hydrochloride (MH) loaded graphene oxide (GO) films on abutment surfaces for peri‐implantitis.
Results
Radiographic and Micro‐CT analysis showed that lots of marginal bone loss could be found on Ti and MH/Ti groups, especially for Ti group. Little bone less could be seen on GO/Ti group while bone less on MH/GO/Ti group was negligible. Results of the histological analysis presented that lots of neutrophils could be found on Ti and MH/Ti groups. However, almost none of the neutrophils could be observed on GO/Ti and MH/GO/Ti while lots of osteocytes could be found.
Conclusion
MH loaded GO films on implant abutment surfaces could prevent the further development of peri‐implantitis and exhibit good therapeutic effect for peri‐implantitis in beagle dogs.
This article is protected by copyright. All rights reserved
from
https://onlinelibrary.wiley.com/doi/abs/10.1002/JPER.19-0285?af=R
No comments:
Post a Comment