Abstract
Background
The 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions grouped the diseases previously recognized as Chronic (ChP) or Aggressive (AgP) periodontitis under a single category named Periodontitis. The rationale for this decision was the lack of specific patterns of immune‐inflammatory response or microbial profiles associated with ChP or AgP. However, no previous studies have compiled the results of all studies comparing subgingival microbial data between these clinical conditions. Thus, this systematic review aimed to answer the following focused question: “Do patients with AgP periodontitis present differences in the subgingival microbiota when compared to patients with ChP periodontitis?”
Methods
A systematic review was conducted according to the PRISMA statement. The MEDLINE, EMBASE and Cochrane databases were searched up to June 2019 for studies of any design (except case reports, case series and reviews) comparing subgingival microbial data from patients with ChP and AgP.
Results
467 papers were identified and 56 were included. Thirteen studies found Aggregatibacter actinomycetemcomitans elevated in AgP in comparison with ChP, while Fusobacterium nucleatum, Parvimonas micra and Campylobacter rectus were elevated in AgP in a few studies. None of these species were elevated in ChP. However, the number of studies not showing statistically significant differences between ChP and AgP was always higher than that of studies showing differences.
Conclusion
These results suggested an association of A. actinomycetemcomitans with AgP, but neither this species nor the other species studied to date were unique to or could differentiate between ChP and AgP (PROSPERO #CRD42016039385).
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https://aap.onlinelibrary.wiley.com/doi/abs/10.1002/JPER.19-0586?af=R
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