Abstract
Background
Association between periodontitis and prostate diseases of benign prostatic hyperplasia (BPH) and prostatitis is uncertain.
Methods
From the National Health Insurance Research Database of Taiwan, 5,510 patients with newly diagnosed chronic periodontitis and participated in therapies were selected from 2000 to 2015 as cohort 1. Matched with age and index year, 5,510 patients with periodontitis diagnosis without therapy were selected as cohort 2, and 5,510 participants without diagnosis were used as control. Cox proportional hazard and survival analysis were performed to compare the risks and the survival probabilities among cohorts.
Results
In two periodontitis cohorts, 636 and 638 participants compared with 550 in control (1,174 and 1.187 vs. 989 per 100,000 person‐years) had prostate disorder. Difference was identified for prostatitis (n = 68, 70 vs 34; rate = 125, 130 vs 61 /100,000 person‐years; p <0.001) but not for BPH (n = 577, 575, vs 529; rate = 1,065, 1,070 vs 951 /100,000 person‐years, respectively). Different survival probabilities for prostate disorder and prostatitis, but not for BPH, were observed among cohorts. Periodontitis patients were more likely to develop prostate disorder after adjustment [adjusted hazard ratio (aHR) of 2.590‐2.641 by competing model]. With stratification, risks between two periodontitis cohorts exhibited no difference. When BPH cases were excluded, the aHRs for prostatitis were 4.611‐4.798.
Conclusions
In spite of treatment, the patients with periodontitis had higher risk of developing prostatitis than patients without periodontitis.
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https://aap.onlinelibrary.wiley.com/doi/abs/10.1002/JPER.19-0706?af=R
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