Abstract
Background
This study aimed to determine and compare soft tissue healing outcomes following implant placement in grafted (GG) and non‐grafted bone (NGG).
Methods
Patients receiving single implant in a tooth‐bound maxillary non‐molar site were recruited. Clinical healing was documented. Volume and content of wound fluid (WF; at 3, 6 and 9 days) were compared with adjacent gingival crevicular fluid (GCF; at baseline, 1 and 4 months). Buccal flap blood perfusion recovery and changes in bone thickness were recorded. Linear mixed model regression analysis and generalized estimating equations with Bonferroni adjustments were conducted for repeated measures.
Results
25 patients (49±4 years; 13 males; 9 NGG) completed the study. Soft tissue closure was slower in GG (p<0.01). Differential response in WF/GCF protein concentrations was detected for ACTH (increased in GG only) and insulin, leptin, osteocalcin (decreased in NGG only) at day 6 (≤0.04), with no inter‐group differences at any time(p>0.05). Blood perfusion rate decreased immediately postoperatively (p<0.01, GG) followed by 3‐day hyperemia (p>0.05 both groups). The recovery to baseline values was almost complete for NGG while GG stayed ischemic even at 4 months (p = 0.05). Buccal bone thickness changes were significant in GG sites (p≤0.05).
Conclusion
History of bone grafting alters the clinical, physiological, and molecular healing response of overlying soft tissues after implant placement surgery.
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from
https://aap.onlinelibrary.wiley.com/doi/abs/10.1002/JPER.19-0709?af=R
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