A novel system exploits bone debris for implant osseointegration

Abstract

Background

Bone debris generated during site preparation is generally evacuated with irrigation; here, we evaluated whether retention of this autologous material improved the rate of peri‐implant bone formation.

Materials and methods

In 25 rats, a miniatured implant system comprised of an osseo‐shaping tool and a tri‐oval shaped implant was compared against a conventional drill and round implant system. A split‐mouth design was used, and fresh extraction sockets served as implant sites. Histology/histomorphometry, immunohistochemistry, and μCT imaging were performed immediately after implant placement, and on post‐surgery days 3, 7, 14 and 28.

Results

Compared to a conventional drill design, the osseo‐shaping tool produced a textured osteotomy surface and viable bone debris that was retained in the peri‐implant environment. Proliferating osteoprogenitor cells, identified by PCNA and Runx2 expression, contributed to faster peri‐implant bone formation. Although all implants osseointegrated, sites prepared with the osseo‐shaping tool showed evidence of new peri‐implant bone sooner than controls.

Conclusion

Bone debris produced by an osseo‐shaping tool directly contributed to faster peri‐implant bone formation and implant osseointegration.

This article is protected by copyright. All rights reserved

from
https://aap.onlinelibrary.wiley.com/doi/abs/10.1002/JPER.20-0099?af=R