Abstract
Background
Aim of the pilot study was the histologic classification of the inflamed peri‐implant soft tissue around ceramic implants (CI) in comparison to titanium implants (TI).
Methods
Peri‐implant tissue were retrieved from 15 patients (age 34‐88 years, 7 male/8 female) with severe peri‐implantitis [8 CI, 7 TI]. The peri‐implant soft tissue samples were retrieved from the sites during scheduled removal of the implant and prepared for immunohistochemical analysis. Monoclonal antibodies (targeting CD3, CD20, CD138, CD68) were used to identify T‐ and B‐cells, plasma cells and macrophages. Quantitative assessment was performed by one histologically trained investigator. Linear mixed regression models were used.
Results
A similar numerical distribution of the cell population was found in peri‐implantitis around CI compared to TI. CD3 (TI 17 – 85% vs CI 20 – 70% of total cell number) and CD138 (TI 1 ‐73% vs CI 12‐69% of total cell number) were predominantly expressed. Notably, patient‐individual differences of numerical cell distribution were detected. Co‐localization of B‐ and T‐lymphocytes was observed.
Conclusion
Peri‐implantitis around CI in comparison with TI seems to have a similar histological appearance. Differences in cellular composition of peri‐implantitis lesions might also depend on the patients specific immune status and not only on the material used.
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https://aap.onlinelibrary.wiley.com/doi/abs/10.1002/JPER.20-0169?af=R
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